We have an invited researcher Dr. R.H. Stierum from TNO, Netherlands, who will be visiting us on 12th of February. We are collaborating with him/TNO in HEALS project. He will be delivering multidisciplinary seminar of DEQ at 12h (Sala de Graus, ETSEQ) entitled: APPLICATION OF SYSTEMS TOXICOLOGY TOWARDS IMPROVED MODEL DEVELOPMENT FOR HUMAN HAZARD AND RISK ASSESSMENT.
FIONA PERIS, TecnATox member, defended her PhD last Friday, January 15th at 12:00 p.m in Sala de Graus, School of Medicine and Health Sciences (FMCS). She obtained the highest qualification excellent cum laude.
Title: "ApoE phenotype expression and its modulation by chlorpyrifos: new insights into gene - toxic interactions". The thesis was directed by Dr. Maria Teresa Colomina and Dr. José Luís Domingo.
The extensive use and massive release of pesticides into the environment has led some authors wonder about the potential contribution of these substances on the emergence of neuropsychiatric and metabolic disorders. Currently, organophosphates (OP) – and chlorpyrifos (CPF) in particular - are the most widely used insecticides in the world. Given the heterogeneity of sources of exposure, most of the population is almost permanently exposed to CPF. Thus, a great body of epidemiological and experimental data have reported neurobehavioural deficits following exposure to the pesticide, and incipient evidence begins to suggest potential links between OPs and metabolic disorders. One of the critical issues is to establish whether there are subpopulations particularly susceptible to the detrimental effects of CPF. It has been proved that human apolipoprotein E (apoE) isoforms confer on their carriers varying vulnerabilities to metabolic diseases and neurodegeneration. The main objective of this thesis was to assess the behavioural and metabolic effects of both APOE genotype and CPF, as well as to determine whether the interaction between both factors contributed to these effects. To test this, adult mice expressing apoE2, apoE3 or apoE4 human isoforms were subchronically exposed to 2 mg/kg/day or 3.75 mg/kg/day CPF depending on the experimental phase. After exposure, animals were behaviourally tested, while the metabolic-disruptor role of CPF was also assessed in paralel. In general, APOE genotype influenced cognitive performance. The exposure to CPF altered metabolic functioning, and induced protracted attentional and motivational deficits. ApoE3 mice were the most vulnerable to the metabolic effects of CPF, and showed memory impairments after exposure. Furthermore, the pesticide reversed the lack of inhibitory control characteristic of apoE4 mice. Taken together, these results expand the existing literature on the behavioural and metabolic effects of CPF, and provide valuable information on gene – toxic interactions hitherto unknown.
Domingo JL and Nadal M (2016) Carcinogenicity of consumption of red and processed meat: What about environmental contaminants? Environmental Research 145: 109-115. Link
Xu C, Ojeda M, Arancon RAD, Romero AA, Domingo JL, Gómez M, Blanco J, Luque R (2015) Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells. Acs Sustain Chem Eng 3: 2716-2725. Link
In December 2015, Thomson Reuters launched an updated list of Highly Cited Researchers. The full list, which is publicly accessible at the website http://highlycited.com/, includes some of world’s most influential scientific minds. A total of 3126 experts of 21 research fields have been selected. These researchers earned the distinction by writing the greatest numbers of reports officially designated by Essential Science Indicators as Highly Cited Papers -ranking among the top 1% most cited for their subject field and year of publication-.
For the second consecutive year, the Director of TecnATox, Prof. José Luis Domingo, has been named as Highly Cited Researcher in the category of Agricultural Sciences. Professor Domingo is the only Highly Cited Researcher of “Rovira i Virgili” University as primary affiliation. Moreover, only 52 investigators from Spanish institutions have been awarded, five of them in the field of Agricultural Sciences. This designation is truly an indication of exceptional impact in the area of food toxicology, in which Prof. Domingo has demonstrated an outstanding expertise and visionary capacity.
TecnATox members will attend the VI Workshop on Sewage Sludges, which will be held in Barcelona in November 25, 2015. Dr. Jordi Sierra has been invited by the organization (University of Barcelona) to give a lecture entitled “Contents of metals and organic contaminants and ecotoxicity of sludges from 28 Spanish WWTPs”. Click here for more information
TecnATox members participated in the 18th International Symposium on Environmental Pollution and Its Impact on Life in the Mediterranean Region, which was held from September 26 to 30, 2015, in Crete, Greece. Link
“Climate change impact on photodegradation and ecotoxicity of PAHs in Mediterranean soils”
“Mixtures of contaminants and complex samples: basic challenges for microalgae-based ecotoxicological tests”
“The HEALS approach to health and environment-wide associations”
“Improving interaction mechanism of metal mixtures (Pb, Cd, Hg, As, Cr) in Generalized Physiological Toxicokinetic Model (PBTK)”