June 2019


EuroMix participated in EPAA Partners Forum: Finding synergies for 3Rs TK and read‐across

On November 21st, the EPAA partners met to build synergies on the development and acceptance of Toxicokinetics and read‐across. Held at the Renaissance Brussels Hotel, the EPAA Partners Forum brought together 33 expert participants from industry and EC, along with selected representatives from regulatory agencies and invited researchers from two large EU‐funded projects (EuroMix and  EUToxRisk). Dr. Vikas Kumar from University of Rovira I Virgili (Spain) represented the EuroMix project in this meeting.  Dr. Kumar presented “Toxicokinetics and read across in EuroMix” and discussed how research in EuroMix is helpful for the wider stakeholders and why collaboration is necessary for the society. The Partners Forum held on 2st of November 2017 was part of the EPAA undertakings to address one of 6 challenges as a priority: to Improve intra and inter sectorial collaboration and coordination.

EPAA is a very relevant platform to build synergies across sectors, given its multi‐sectoral structure encompassing different business sectors. Besides exchanging information between sectors about their respective research agendas and activities in the sectorial flagship initiatives, the event was meant as an opportunity for the partners to identify possibilities for synergies, table feedback and scientific input in EPAA. Discussions revolved around 4 balanced sessions aiming at covering the whole spectrum of stakeholders working on TK and read‐across: regulators, the regulated, method developers and downstream users.

At the end of the day, a scientific consensus was achieved on the following four items:

• TK data play an important role in risk assessment across all industry sectors and are subject to significant research effort by all relevant stakeholders

• TK data strengthen the read across weight of evidence; TK data should ideally be anchored towards human relevance, preferably generated using in silico and in vitro tools

• Identification and characterization of Metabolism is a key component of TK assessment in readacross

• The forum expressed confidence that significantly more progress in TK can be made if collaboration between sectors is enhanced and synergies are captured.

Specifically, the participants recommended 3 actions to tackle the use of TK and read‐across methods:

– ACTION 1: Advocate for a TK speciality section within Eurotox

– ACTION 2: Produce and manage a shopping list of open tools (open source, EPAA controlled)

– ACTION 3: Support the dissemination and training event on RVIS planned in early 2019 with TK stakeholders

The participants’ discussion was captured by a scientific writer and a scientific publication is currently under preparation.

Posted on 11-12-2017