Roser Esplugas, PhD candiate in the Radiobiology area, will attend to the 44th European Radiation Research Congress (ERR 2018). It will be held in Pécs (Hungary) from August 21 to 25, 2018. She will be presenting the following posters:
Roser Esplugas, Noemí Serra, Montserrat Bellés, Victoria Linares, Meritxell Arenas, Joan Carles Vallvé. Effect of 2 Gy-radiation on the expression of miRNAs-146a, -155, -221 and -222 in HUVECs.
Roser Esplugas, Noemí Serra, Montserrat Bellés, Victoria Linares, Meritxell Arenas, Joan Carles Vallvé. Effect of radiotherapy, molecular parameters and treatment on the expression of blood miRNAs-146a, -155, -221 and -222 in women with breast cancer.
Schreiber E, Alfageme O, Garcia T, González N, Sirvent JJ, Torrente M, Gómez M, Domingo JL. Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring. Food Chem Toxicol. 2019 Apr 12;128:193-201.
González N, Marquès M, Nadal M, Domingo JL. Levels of PCDD/Fs in foodstuffs in Tarragona County (Catalonia, Spain): Spectacular decrease in the dietary intake of PCDD/Fs in the last 20 years. Food Chem Toxicol. 2018 Aug 23. pii: S0278-6915(18)30592-1. doi: 10.1016/j.fct.2018.08.035.
Sharma RP, Schuhmacher M, Kumar V. Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach. Toxicol Lett. 2018 Oct 15;296:152-162. doi: 10.1016/j.toxlet.2018.06.1217. Epub 2018 Jun 26.
Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S. Alterations in morphology and adult neurogenesis in the dentate Gyrus of Patched1 Heterozygous Mice. Front Mol Neurosci. 2018 May 23;11:168. doi: 10.3389/fnmol.2018.00168. eCollection 2018.
The Spanish Ministry of Science, Innovation and Universities has just communicated the provisional resolution of the I+D+i "Retos de investigación" ("Research challenges") of the State program of I+D+i adressed to the society challenges corresponding to the call of 2018.
After 8 months of evaluation process, the proposal entitled "Sources, exposure and human health risks of classic and emerging flame retardants in indoor environments of Spain. Integrated approach of human health risk." presented by Prof. Marta Schuhmacher (IP) has been proposed to be funded.
HEALS (Health and Environmet-wide Associations based on Large population Surveys) has recently launched the 7th issue of the HEALS newsletter. This issue is about: an article that reveals the risks of prenatal exposures to bisphenol A and the dynamics of metabolic reactivation, using a PBPK modeling at pregnancy; the funciton of an open platform elaborated by HEALS; the numerous documents and data files currently available in this online platform designed for external training; a paper on the human exposure to organophosphate and pyrethroid pesticides, specifically in occupationally-exposed and general populations living in rural and urban areas.
Prof. Josep Lluís Domingo, Dr. Vikas Kumar, Neus González, María Ángeles Martínez, Elga Schreiber and Raju P. Sharma are currently to the 54th Congress of the European Societies of Toxicology (EUROTOX 2018), which is held in Brussels (Belgium) from September 2 to 5. They have the following poster presentations:
González N, Marquès M, Nadal M, Domingo JL. Dietary intake of PCDD/Fs by the population of Tarragona County, Catalonia, Spain. Temporal trends (1998-2018).
González N, Schreiber E, Alfageme O, Torrente M, Domingo JL, Gómez M. Assessment of reproductive toxicity of male rats through maternal exposure to dienestrol.
Kumar V, Karri V, Edwin M, Coort S, Evelo C, Oliveira E, Schuhmacher M. A system-based comparative proteomics approach to investigate heavy metals mixtures toxicity mechanism relates to the neurodegeneration on hippocampal cell line.
Martínez MA, Rovira J, Sharma RP, Nadal M, Schuhmacher M, Kumar V. Prediction and evaluation of the internal dosimetry of two wide spread endocrine disruptors in fetus using a physiologically based pharmacokinetic model.
Schreiber E, Garcia T, Torrente M, Kumar V, Sharma RP, Domingo JL, Gómez M. Assessment of the oxidative stress effects on the reproductive system of young male rats to n-butylparaben.
Sharma RP, Kumar V, Schuhmacher M. PBPK/PD coupled HPG SB model to analyze the reproductive toxicity of EDs: case study on mixture effects of DEHP and TCDD.
Prof. Domingo has been recently interviewed by SINC La Ciencia es Noticia (Science is news) and La Vanguardia. The reason of such interview was the last TecnATox research focused on the occurrence of toxic chemical compounds in clothes and related human health risks.
The textile industry uses toxic compounds affecting the environment, but also the health of such industry workers. Recent studies indicate that depending on the use and kind of clothes, consumers might suffer more than just a cutaneous allergy. These risks are not properly considered by the regulations of textile products. You can read the full press releases in the following links:
Marquès M, Cervelló D, Mari M, Sierra J, Schuhmacher M, Domingo JL, Nadal M. The role of iron oxide on the photodegradation of polycyclic aromatic hydrocarbons: characterization and toxicity. Polycycl Aromat Comp. 2018 Apr 19. doi: 10.1080/10506638.2018.1458743.
Ferre-Rey G, Sánchez-Rodríguez J, Llorca-Linares M, Vicens P, Camps M, Torrente M, Morales-Vives F. A systematic review of instruments for early detection of autism spectrum disorders. Int J of Psychol Psychol Ther. 2019 Jan; 19, 29-38.
Tomas-Roig J, Torrente M, Cabré M, Vilella E, Colomina MT. Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal. Behav Brain Res. 2019 May; 363, 38-44. doi: 10.1016/j.bbr.2019.01.036
González N, Marquès M, Nadal M, Domingo JL. Occurrence of environmental pollutants in foodstuffs: A review of organic vs. conventional food. Food Chem Toxicol. 2019 Jan; 125, 370-375. doi:10.1016/j.fct.2019.01.021
Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Sánchez-Santed F, Domingo JL, Colomina MT. Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype. Arch Toxicol. 2019 Jan 18. doi: 10.1007/s00204-019-02387-9.
Domínguez-Morueco N, Ratola N, Sierra J, Nadal M, Jiménez-Guerrero P.Combining monitoring and modelling approaches for BaP characterization over a petrochemical area. Sci Total Environ. 2018 Dec 15;658:424-438. doi: 10.1016/j.scitotenv.2018.12.202.
Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL. Trace element concentrations in breast cancer patients. Breast. 2018 Oct 1;42:142-149. doi: 10.1016/j.breast.2018.09.005.
Trabalón L, Alves RN, Castro Ó, Nadal M, Borrull F, Pocurull E, Marques A. Preliminary assessment of galaxolide bioaccessibility in raw and cooked fish. Food Chem Toxicol. 2018 Dec;122:33-37. doi: 10.1016/j.fct.2018.09.075.
Crépet A, Vanacker M, Sprong C, de Boer W, Blaznik U, Kennedy M, Anagnostopoulos C, Christodoulou DL, Ruprich J, Rehurkova I, Domingo JL, Hamborg Jensen B, Metruccio F, Moretto A, Jacxsens L, Spanoghe P, Senaeve D, van der Voet H, van Klaveren J. Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis. Int J Hyg Environ Health. 2018 Dec 19. pii: S1438-4639(18)30548-0. doi: 10.1016/j.ijheh.2018.12.002. [Epub ahead of print]
Rovira J, Domingo JL. Human health risks due to exposure to inorganic and organic chemicals from textiles: A review. Environ Res. 2019 Jan;168:62-69. doi: 10.1016/j.envres.2018.09.027. Epub 2018 Sep 24. Review.
Guardia-Escote L, Basaure P, Blanco J, Cabré M, Pérez-Fernández C, Sánchez-Santed F, Domingo JL, Colomina MT. Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner. Food Chem Toxicol. 2018 Dec;122:1-10. doi: 10.1016/j.fct.2018.09.069. Epub 2018 Sep 29.
Suzuki MN, Fregonesi BM, Machado CS, Zagui GS, Kusumota L, Suzuki AK, da Costa JAC, Llopart JS, Nadal M, Domingo JL, Segura-Muñoz S. Hemodialysis Water Parameters as Predisposing Factors for Anemia in Patients in Dialytic Treatment: Application of Mixed Regression Models. Biol Trace Elem Res. 2018 Sep 14. doi: 10.1007/s12011-018-1515-7. [Epub ahead of print]
Peña-Casanova J, Torrente M, Pino M, Lorente P, Quiñones-Úbeda S (2019). Capítulo XIV. Introducción al perfil funcional (actividades de la vida diària). pp 438-446. Peña-Casanova J. Teoría e Interpretación: Normalidad, Semiología y Patología Neuropsicológicas. Programa integrado de exploración neuropsicológica. Test Barcelona-2. Masquelibros, S.L., Jaén. ISBN: 978-84-120274-0-2. Depósito legal: B-9745-2019
Berasaluce M, Mondaca P, Schuhmacher M, Bravo M, Sauvé S, Navarro-Villarroel C, Dovletyarova EA, Neaman A. Soil and indoor dust as environmental media of human exposure to As, Cd, Cu and Pb near a copper smelter in central Chile (2019) J Trace Elem in Med Biol 54, 156-162.
The coordinating Committee of Nanomed Spain accepted the adhesion of TecnATox on the Spanish nanomedicine platform, also called Nanomed Spain. The Platform is committed to work as efficiently as possible with the available resources to consolidate the good position of Spain in this emerging area, where it is located in the leading group at an international level.
Schuhmacher M, Mari M, Nadal M, Domingo JL. Concentrations of dioxins and furans in breast milk of women living near a hazardous waste incinerator in Catalonia, Spain. Environ Int. 2019 Apr; 125: 334-341. doi: 10.1016/j.envint.2019.01.074.
Esparza JL, Gómez M, Domingo JL. Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review. Biol Trace Elem Res. 2018 May 7. doi: 10.1007/s12011-018-1372-4.
Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Sánchez-Santed F, Domingo JL, Colomina MT. Postnatal chlorpyrifos exposure and apolipoprotein E (APOE) genotype differentially affect cholinergic expression and developmental parameters in transgenic mice. Food Chem Toxicol. 2018 May 2. pii: S0278-6915(18)30289-8. doi: 10.1016/j.fct.2018.04.065.
Rovira J, Sierra J, Nadal M, Schuhmacher M, Domingo JL. Main components of PM10 in an area influenced by a cement plant in Catalonia, Spain: Seasonal and daily variations. Environ Res. 2018 May 1;165:201-209.
María Ángeles Martínez, PhD student of the Health Risk Assessment and Food Toxicology area, attended to the 8th Young Environmental Scientist (YES) Meeting of SETAC. It was celebrated in Ghent (Belgium) from 5th to 10th February 2019.
María Ángeles presented some exciting findings of her thesis in the following poster:
Martínez MA, Rovira J, Kumar V, Schuhmacher M. Tarragona mother-child exposure assessment to wide spread endocrine disruptors (EDs) and in-vitro EDs exposure effects on adipogenesis.
Prof. Josep Lluís Domingo, Prof. Marta Schuhmacher, Dr. Joaquim Rovira and María Ángeles Martínez are attending to SETAC Europe 28th Annual Meeting, which is held in Rome from 13 to 17 May. They are presenting the following research findings:
TU393 Sánchez-Soberón F, Noardo F, Mari M, Kumar V, Schuhmacher M. Good news to lazybones kids: increasing sleeping time decreases exposure to airborne particulate matter.
TU392 Sánchez-Soberón, Rovira J, Sierra J, Schuhmacher M. How risky is the schoolyard? An approach from chemical composition of particulate matter.
TU389 Sánchez-Soberón, Serra N, Linares V, Bellés M, Schuhmacher M. Toxicity of airborne particulate matter as a factor to choose the most convenient school.
WE244 Marquès M, Mari M, Nadal M, Schuhmacher M, Domingo JL. Nothing is what it seems: Levels of PCDD/Fs in the surroundings of a hazardous waste incinerator.
TH075 Martínez Rodríguez M, Sharma RP, Nadal M, Kumar V, Schuhmacher M. Dietary and non-dietary prenatal exposure to endocrine disruptors (BPA and DEHP). Spanish case study.
Esparza JL, Gómez M, Domingo JL. Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review. Biol Trace Elem Res. 2019 Mar;188(1):60-67.
Schuhmacher M, Mari M, Nadal M, Domingo JL. Concentrations of dioxins and furans in breast milk of women living near a hazardous waste incinerator in Catalonia, Spain. Environ Int. 2019 Feb 7;125:334-341. doi: 10.1016/j.envint.2019.01.074
Dr. Francisco García, forensic doctor and researcher of the Toxicology area of TecnATox, has been awarded with "Creu de Sant Ramon de Penyafort".
You can read the full press release in the following link.
For a cleaner and healthier air in Kathmandu, The Ministry of Health and Population (MoHP) and World Health Organization (WHO) – Nepal organized “Introductory Training on Health Impact Assessment/Health Economics and Data Analysis Workshop”, a five-day session with 35 representatives from different government agencies working on air quality and related experts, from national and international government organizations, academia, hospitals and representatives from Government of Maldives and WHO offices (HQ, SEARO, India, and Nepal country offices). Dr. Joaquim Rovira, expert in atmospheric pollution of TecnATox, joined the course as a WHO external assessor. You can find more information in the WHO press release.
Dr. Francisco Sánchez-Soberón, postdoctoral researcher in TecnATox, gave a talk in the Department of Toxic Substances Control of California EPA last Wednesday 23rd May.
The presentation was entitled: "Assessment of human health risks and toxicity associated to particles (10, 2.5, and 1), organic pollutants, and heavy metals nearby cement plants".
Herrero M, Rovira J, Nadal M, Domingo JL. Risk assessment due to dermal exposure of trace elements and indigo dye in jeans: Migration to artificial sweat. Environ Res. 2019 Feb 22;172:310-318. doi: 10.1016/j.envres.2019.02.030.
Sarigiannis DA, Karakitsios S, Dominguez-Romero E, Papadaki K, Brochot C, Kumar V, Schumacher M, Sy M, Mielke H, Greiner M, Mengelers M, Scheringer M. Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative. Environ Res. 2019 Jan 29;172:216-230. doi: 10.1016/j.envres.2019.01.045.
Dr. Jaume Folch, researcher in TecnATox, has recently published his third book entitled "El naufragi dels records. Què hi ha darrere de malalties com l'Alzheimer?" (The shipwreck of memories. What is behind Alzheimer disease?).
The book is about how the new advances in the understanding of the disease allow us to determine the origin and to influence on their prevention through diet or physical exercise, among others. You can find more information in the URV digital press release.
Prof. Francisco García, researcher of the area of Toxicology and medical examiner at the Institute of Legal Medicine and Forensic Sciences of Catalonia, will attend the 22th Scientific Meeting of the Spanish Association of Forensic Doctors and the Legal Medicine School. This meeting will take in March 8th 2019, in the “Centro de Estudios Jurídicos”, Madrid. The conference brings national renowned speakers, as well as the participation of researchers and university students who will present their work and innovations in this field of Forensic Medicine. Dr. García will present the following communications:
Caballero P, García-Sayago F, Soler A, Torralba P, Segú E, Correas C, Landín I, Altés J, Suelves JM, Barbería E. Análisis descriptivo de una serie de muertes por caídas accidentales en mayores de 65 años.
Landín I, Azeli Y, Torralba P, García-Sayago F, Laguna C, Alvarez R, Bardají A, Barbería E. Incidencia de lesiones óseas y viscerales graves secundarias a RCP: resultado de una serie autópsica.
Martínez MA, Rovira J, Sharma RP, Nadal M, Schuhmacher M, Kumar V.Comparing dietary and non-dietary source contribution of BPA and DEHP to prenatal exposure: A Catalonia (Spain) case study. Environ Res. 2018 Oct. doi: 10.1016/j.envres.2018.05.008.
Cano A, Ettcheto M, Chang JH, Barroso E, Espina M, Kühne BA, Barenys M, Auladell C, Folch J, Souto EB, Camins A, Turowski P, García MLJ. Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model. Control Release. 2019 Mar 13;301:62-75. doi: 10.1016/j.jconrel.2019.03.010. [Epub ahead of print]
TecnATox celebrated the annual workshop and strategic plan meeting on May 31 in the School of Medicine and Health Science.
PhD students presented their project thesis during the first half of the morning. After the coffee break, the strategic plan meeting was carried out. Upcoming objectives of the group were discussed and actions were defined.
"El naufragi dels records. Què hi ha darrere de malalties com l'Alzheimer?" (The shipwreck of memories. What is behind Alzheimer's disease?) by Dr. Jaume Folch will be presented on April 4 at 7PM in Galatea bookstore (Reus).
This book explains, with an understandable and at the same time rigorous language, why diseases like this deprive us of memories, emotions, affection. It is also about the most surprising theories in the field of neuroscience and reveals the keys to future therapies. We live an extraordinary moment in the search for new treatments for brain disorders that will open a new era for humanity.
The doctoral programme in Nanosciences, Materials and Chemical Engineering organises a day in which doctoral students have the opportunity to discuss their work and have it evaluated by a prestigious panel of experts during a platform and a poster exhibition sessions.
The TecnATox member María Ángeles Martínez presented her work in the platform session, which was entitled: "Comparing dietary and non-dietary source contribution of BPA and DEHP to prenatal exposure: A Catalonia (Spain) case study".
Nadal M, Mari M, Schuhmacher M, Domingo JL. Monitoring dioxins and furans in plasma of individuals living near a hazardous waste incinerator: Temporal trend after 20 years. Environ Res. 2019 June; 173, 207-211. doi: 10.1016/j.envres.2019.03.051
Marquès M, Nadal M, Díaz-Ferrero J, Schuhmacher M, Domingo JL. Concentrations of PCDD/Fs in the neighborhood of a hazardous waste incinerator: human health risks. Environmental Science and Pollution Research (2018) doi: 10.1007/s11356-018-2685-8
Sharma RP, Schuhmacher M, Kumar V. Development of a human physiologically based pharmacokinetic (PBPL) model for phthalate (DEHP) and its metabolites: a bottom up modeling approach. Toxicology Letters (2018) doi: 10.1016/j.toxlet.2018.06.1217
Sánchez-Soberón F, Cuykx M, Serra N, Linares V, Bellés M, Covaci A, Schuhmacher M. In-vitro metabolomics to evaluate toxicity of particulate matter under environmentally realistic conditions. Chemosphere (2018) doi: 10.1016/j.chemosphere.2018.06.065
TecnATox will be in SETAC Europe 29th Annual meeting, which is held in Helsinki (Finland) from May 26th to May 30th 2019. Over the 5 days of conference, 4 PhD students and 3 Postdoctoral researchers of TecnATox will carry out the following presentations:
Martínez MA, Rovira J, Sharma RP, Nadal M, Kumar V, Schuhmacher M. How much do dietary and non-dietary sources contribute to prenatal exposure to BPA and DEHP? A Catalonia (Spain) case study. Presentation type: Platform Presentation. Date: Thursday May 30th, 2019.
Rovira J, Martínez MA, Espuis T, Sharma RP, Nadal M, Kumar V, Costopoulou D, Vassiliadou I, Leondiadis L, Domingo JL, Schuhmacher M. Prenatal exposure to PFOS and PFOA in a Catalan pregnant women cohort. Presentation type: Platform Presentation. Date: Thursday May 30th, 2019.
Carafa R, Sierra J, Expósito N, Munné A, Gallé T, Schmitt-Jansen M, Schuhmacher M. TOXMIC: TOXicants monitoring chamber for MICrocontaminants. Presentation type: Poster spotlight. Presentation date: Monday May 27th, 2019.
Expósito N, Rovira J, Sierra J, Folch J, Schuhmacher M. Micro(Nano)plastic Pollution: Tackling the plastic problem by identifying sources, investigating fate and novel approaches (PC). Presentation type: Poster Corner. Presentation date: Monday May 27th, 2019.
González N, Cunha S, Monteiro C, Fernandes J, Marquès M, Nadal M, Domingo JL. Quantification of 9 bisphenol analogues in total blood, plasma and urine samples from a cohort of workers through a DLLME extraction followed by GC-MS determination. Presentation type: Poster. Presentation date: Tuesday May 28th, 2019.
Marquès M, Mari M, Nadal M, Schuhmacher M, Domingo JL. Human biomonitoring of a non-occupationally exposed population living near a hazardous waste incinerator: Temporal trends of PCDD/Fs in plasma. Presentation type: Poster. Presentation date: Monday May 27th, 2019
Martínez MA, Blanco J, Rovira J, Kumar V, Schuhmacher M. Do the principals analogues of bisphenol A have endocrine activity? In vitro case study. Presentation type: Poster. Presentation date: Wednesday May 29th, 2019.
Schreiber E, González N, Kumar V, Torrente M, Domingo JL, Gómez M. Feminization effects on male offspring rats through maternal exposure to flutamide, linuron and dienestrol. Presentation type: Poster. Presentation date: Wednesday May 29th, 2019.
Mari M, Rovira J, Sánchez-Soberón F, Nadal M, Schuhmacher M, Domingo JL. Partial replacement of fossil fuels in a cement plant: Assessment of human health risks by metals, metalloids and PCDD/Fs. Environ Res. 2018 Jul 19;167:191-197. doi: 10.1016/j.envres.2018.07.014.
Sakamoto M, Tatsuta N, Chan HM, Domingo JL, Murata K, Nakai K. Brain methylmercury uptake in fetal, neonate, weanling, and adult rats. Environ Res. 2018 Jul 5;167:15-20. doi: 10.1016/j.envres.2018.06.038.
The presentation of Test Barcelona-2 and the Online Neuropsychological Workstation will take place in Barcelona (Mar Teaching Unit, 80 Dr. Aiguader) on May 16th and 17th 2019. The workshop "Neuropsychological exploration: technological and conceptual advances" focuses on the impact of advances in cognitive neuroscience and Internet technologies in the neuropsychological clinic, and specifically in the new version of the Barcelona Test.
In the framwork of this event, Dr. Margarita Torrente, codirector of Neuropsychology and emotions area of TecnATox, will perform a presentation entitled: "The scale of daily life activities of Test Barcelona". You can find the full program here.
Prof. Josep Lluís Domingo has recently been interviewed in betevé. He talked about the high concentrations of dioxins reported in the surroundings of the municipal waste incinerator located in Sant Adrià del Besos (Barcelona). He asks for immediate measures to reduce the emissions of dioxins in the aforementioned facility, which were found up to 2.3 times the acceptable threshold.
You can watch the full interview in the following link.
EuroMix project is arriving to the end. Dr. Vikas Kumar, Dr. Margarita Torrente, Neus González and Elga Schreiber will attend to the final consortium meeting. It will be held in Egmond aan Zee from April 9th to 11th 2019.
EuroMix (euromixproject.eu) has been a joint effort of 22 European partners and 4 non-EU affiliated partners aimed at delivering a mixture test strategy and test instruments using novel techniques as recently proposed by the Joint Research Centre (JRC) of the European Commission. TecnATox has been actively involved in the project, participating in animal experimentation studies, PBPK modeling, exposure assessment and risk evaluation.
Venkatanaidu Karri, PhD candidate in TecnATox, will defend his doctoral thesis on 9th April 2018, at 9.30h in Sala de Graus, Chemical Engineering School, Universitat Rovira i Virgili.
Title: "Integrated In vitro - Omics based approach to assess the heavy metals and their binary mixtures toxicity in hippocampal HT-22 cell line".
Supervisors: Dr. Marta Schuhmacher and Dr. Vikas Kumar.
TecnATox practiced two field investigations in the vicinity of Besòs incinerator in 2014 and 2017. These studies pointed to an increased risk of cancer in inhabited areas near the plant, the that more waste burns in Catalonia with about 400,000 tons per year. The concern that caused in neighboring neighborhoods, with some 56,000 neighbors, impacted on the platform Aire Net, which has denounced before the Prosecutor alleged illegalities to hide the pollution that blames the plant. The alarm has forced the Metropolitan Area of Barcelona (AMB) and the City Council of the capital -owners of the public company Tersa, which manages the installation- to commission new studies.
Rovira J, Schuhmacher M, Nadal M, Domingo JL. Contamination by coal dust in the neighborhood of the Tarragona Harbor (Catalonia, Spain): A preliminary study. The Open Atm J. 2018; 12:14-20. doi:10.2174/1874282301812010014.
Dr. Jaume Folch, researcher of TecnATox, has recently published a book. It is entitled "El naufragi dels records. Què hi ha darrere de malalties com l'Alzheimer?" (The shipwreck of memories. What is behind Alzheimer's disease?). This book explains, with an understandable and at the same time rigorous language, why diseases like this deprive us of memories, emotions, affection. It is also about the most surprising theories in the field of neuroscience and reveals the keys to future therapies. We live an extraordinary moment in the search for new treatments for brain disorders that will open a new era for humanity.
Dr. Jaume Folch will be signing the book in Rambla Catalunya (Tarragona) next April 23, in the framework of Sant Jordi's day.
Venkatanaidu Karri obtained the PhD degree with the highest qualitification Excellent Cum Laude.
The thesis entitled: "Integrated In vitro - Omics based approach to assess the heavy metals and their binary mixtures toxicity in hippocampal HT-22 cell line" was supervised by Prof. Marta Schuhmacher and Dr. Vikas Kumar.
Blanco J, Tomás-Hernández S, García T, Mulero M, Gómez M, Domingo JL, Sánchez DJ. Oral exposure to silver nanoparticles increases oxidative stress markers in the liver of male rats and deregulates the insulin signalling pathway and p53 and cleaved caspase 3 protein expression. Food Chem Toxicol. 2018 Mar 28. pii: S0278-6915(18)30188-1. doi: 10.1016/j.fct.2018.03.039.
As a part of the dissemination plan, TecnATox researchers are currently giving talks to the general population.
Dr. Francisco Sánchez-Soberón did the presentatation entitled "Has the air that we breath a good quality? How to measure and assess it" in the High School Flix.
Prof. Teresa Colomina, director of Neurotoxicology, Psichopharmacology and Behavioral Science area, has been awarded as distinguished professor.
TecnATox currently accounts with three distinguished professors, as Prof. José Luis Domingo and Prof. Marta Schuhmacher already have such distinction. This is a great milestone.
Francisco Sánchez Soberón obtained the PhD degree with the highest qualitification Excellent Cum Laude.
The thesis entitled: "Assessment of the human health risks and toxicity associated to particles (PM10, PM2.5 and PM1), organic pollutants and metals around cement plants" was supervised by Prof. Marta Schuhmacher and Dr. Joaquim Rovira.
Dr. Jaume Folch is investigating the origin of Alzheimer disease in collaboration with the Universitat de Barcelona. Several studies carried out with animal models show that diet is a key factor for the occurrence of the most common type of such dementia. Specifically, the diabetes during adulthood (type 2 diabetes) would be a determining factor leading to neuronal death and the characteristic memory loss of Alzheimer.
You can read the full press release at Diari Digital URV.
The MELODI Board wants to reward each year one young researcher, active in the domains covered by the activities of the MELODI Association, in order to raise more attention for research in the domain of low doses of ionizing radiation in a broader sense, and to stimulate young researchers to be active and to publish in this domain of activities. You can find more information at the Announcement and Rules for administration of a MELODI Award and at MELODI'S website. DEADLINE: June 15, 2018.
Rovira J, Hernández-Aguilera A, Luciano-Mateo F, Cabré N, Baiges-Gaya G, Nadal M, Martín-Paredero V, Camps J, Joven J, Domingo JL. Trace Elements and Paraoxonase-1 Activity in Lower Extremity Artery Disease. Biol Trace Elem Res. 2018 Mar 10. doi: 10.1007/s12011-018-1298-x.
María Ángeles Martínez, Raju Prasad, Dr. Joaquim Rovira, Dr. Vikas Kumar and Prof. Marta Schuhmacher have created a mathematical model to quantify the transferred amount of bisphenol A from pregnant women to fetus. This method has been tested with 100 pregnant women to know the fate and behavior of bisphenol A in their body and to study the impact on baby's health in the future.
You can read the full press release in the following links:
On November 21st, the EPAA partners met to build synergies on the development and acceptance of Toxicokinetics and read‐across. Held at the Renaissance Brussels Hotel, the EPAA Partners Forum brought together 33 expert participants from industry and EC, along with selected representatives from regulatory agencies and invited researchers from two large EU‐funded projects (EuroMix and EUToxRisk). Dr. Vikas Kumar from University of Rovira I Virgili (Spain) represented the EuroMix project in this meeting. Dr. Kumar presented “Toxicokinetics and read across in EuroMix” and discussed how research in EuroMix is helpful for the wider stakeholders and why collaboration is necessary for the society. The Partners Forum held on 2st of November 2017 was part of the EPAA undertakings to address one of 6 challenges as a priority: to Improve intra and inter sectorial collaboration and coordination.
EPAA is a very relevant platform to build synergies across sectors, given its multi‐sectoral structure encompassing different business sectors. Besides exchanging information between sectors about their respective research agendas and activities in the sectorial flagship initiatives, the event was meant as an opportunity for the partners to identify possibilities for synergies, table feedback and scientific input in EPAA. Discussions revolved around 4 balanced sessions aiming at covering the whole spectrum of stakeholders working on TK and read‐across: regulators, the regulated, method developers and downstream users.
At the end of the day, a scientific consensus was achieved on the following four items:
• TK data play an important role in risk assessment across all industry sectors and are subject to significant research effort by all relevant stakeholders
• TK data strengthen the read across weight of evidence; TK data should ideally be anchored towards human relevance, preferably generated using in silico and in vitro tools
• Identification and characterization of Metabolism is a key component of TK assessment in readacross
• The forum expressed confidence that significantly more progress in TK can be made if collaboration between sectors is enhanced and synergies are captured.
Specifically, the participants recommended 3 actions to tackle the use of TK and read‐across methods:
– ACTION 1: Advocate for a TK speciality section within Eurotox
– ACTION 2: Produce and manage a shopping list of open tools (open source, EPAA controlled)
– ACTION 3: Support the dissemination and training event on RVIS planned in early 2019 with TK stakeholders
The participants’ discussion was captured by a scientific writer and a scientific publication is currently under preparation.
Noelia Domínguez-Morueco, PhD student in TecnATox, is currently attending to the 8th European Meeting on Environmental Chemistry (EMEC). She will perform an oral presentation entitled: "Combining monitoring and modelling approaches for BaP characterization over a petrochemical area" on November 27, 2017.
Sakamoto M, Chan HM, Domingo JL, Koriyama C, Murata K. Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood. Environ Int. 2017 Nov 14. pii: S0160-4120(17)31561-1. doi: 10.1016/j.envint.2017.11.001.
Center of Environmental Food and Toxicological Technology, Rovira i Virgili University (URV)
School of Medicine and Health Sciences (FMCS) C./ Sant Llorenç, 21 (43201) Reus, Catalonia (Spain)
Technical School of Chemical Engineering (ETSEQ) Av. Països Catalans, 26 (43007) Tarragona, Catalonia (Spain)
Faculty of Education and Psychology (FCEP) C/Carretera de Valls, s/n 26 (43007) Tarragona, Catalonia (Spain)