HEALS (Health and Environmet-wide Associations based on Large population Surveys) has recently launched the 7th issue of the HEALS newsletter. This issue is about: an article that reveals the risks of prenatal exposures to bisphenol A and the dynamics of metabolic reactivation, using a PBPK modeling at pregnancy; the funciton of an open platform elaborated by HEALS; the numerous documents and data files currently available in this online platform designed for external training; a paper on the human exposure to organophosphate and pyrethroid pesticides, specifically in occupationally-exposed and general populations living in rural and urban areas.
Marquès M, Cervelló D, Mari M, Sierra J, Schuhmacher M, Domingo JL, Nadal M. The role of iron oxide on the photodegradation of polycyclic aromatic hydrocarbons: characterization and toxicity. Polycycl Aromat Comp. 2018 Apr 19. doi: 10.1080/10506638.2018.1458743.
Venkatanaidu Karri, PhD candidate in TecnATox, will defend his doctoral thesis on 9th April 2018, at 9.30h in Sala de Graus, Chemical Engineering School, Universitat Rovira i Virgili.
Title: "Integrated In vitro - Omics based approach to assess the heavy metals and their binary mixtures toxicity in hippocampal HT-22 cell line".
Supervisors: Dr. Marta Schuhmacher and Dr. Vikas Kumar.
TecnATox practiced two field investigations in the vicinity of Besòs incinerator in 2014 and 2017. These studies pointed to an increased risk of cancer in inhabited areas near the plant, the that more waste burns in Catalonia with about 400,000 tons per year. The concern that caused in neighboring neighborhoods, with some 56,000 neighbors, impacted on the platform Aire Net, which has denounced before the Prosecutor alleged illegalities to hide the pollution that blames the plant. The alarm has forced the Metropolitan Area of Barcelona (AMB) and the City Council of the capital -owners of the public company Tersa, which manages the installation- to commission new studies.
Rovira J, Schuhmacher M, Nadal M, Domingo JL. Contamination by coal dust in the neighborhood of the Tarragona Harbor (Catalonia, Spain): A preliminary study. The Open Atm J. 2018; 12:14-20. doi:10.2174/1874282301812010014.
Dr. Jaume Folch, researcher of TecnATox, has recently published a book. It is entitled "El naufragi dels records. Què hi ha darrere de malalties com l'Alzheimer?" (The shipwreck of memories. What is behind Alzheimer's disease?). This book explains, with an understandable and at the same time rigorous language, why diseases like this deprive us of memories, emotions, affection. It is also about the most surprising theories in the field of neuroscience and reveals the keys to future therapies. We live an extraordinary moment in the search for new treatments for brain disorders that will open a new era for humanity.
Dr. Jaume Folch will be signing the book in Rambla Catalunya (Tarragona) next April 23, in the framework of Sant Jordi's day.
Venkatanaidu Karri obtained the PhD degree with the highest qualitification Excellent Cum Laude.
The thesis entitled: "Integrated In vitro - Omics based approach to assess the heavy metals and their binary mixtures toxicity in hippocampal HT-22 cell line" was supervised by Prof. Marta Schuhmacher and Dr. Vikas Kumar.
Blanco J, Tomás-Hernández S, García T, Mulero M, Gómez M, Domingo JL, Sánchez DJ. Oral exposure to silver nanoparticles increases oxidative stress markers in the liver of male rats and deregulates the insulin signalling pathway and p53 and cleaved caspase 3 protein expression. Food Chem Toxicol. 2018 Mar 28. pii: S0278-6915(18)30188-1. doi: 10.1016/j.fct.2018.03.039.
As a part of the dissemination plan, TecnATox researchers are currently giving talks to the general population.
Dr. Francisco Sánchez-Soberón did the presentatation entitled "Has the air that we breath a good quality? How to measure and assess it" in the High School Flix.
Prof. Teresa Colomina, director of Neurotoxicology, Psichopharmacology and Behavioral Science area, has been awarded as distinguished professor.
TecnATox currently accounts with three distinguished professors, as Prof. José Luis Domingo and Prof. Marta Schuhmacher already have such distinction. This is a great milestone.
Francisco Sánchez Soberón obtained the PhD degree with the highest qualitification Excellent Cum Laude.
The thesis entitled: "Assessment of the human health risks and toxicity associated to particles (PM10, PM2.5 and PM1), organic pollutants and metals around cement plants" was supervised by Prof. Marta Schuhmacher and Dr. Joaquim Rovira.
Dr. Jaume Folch is investigating the origin of Alzheimer disease in collaboration with the Universitat de Barcelona. Several studies carried out with animal models show that diet is a key factor for the occurrence of the most common type of such dementia. Specifically, the diabetes during adulthood (type 2 diabetes) would be a determining factor leading to neuronal death and the characteristic memory loss of Alzheimer.
You can read the full press release at Diari Digital URV.
The MELODI Board wants to reward each year one young researcher, active in the domains covered by the activities of the MELODI Association, in order to raise more attention for research in the domain of low doses of ionizing radiation in a broader sense, and to stimulate young researchers to be active and to publish in this domain of activities. You can find more information at the Announcement and Rules for administration of a MELODI Award and at MELODI'S website. DEADLINE: June 15, 2018.
Rovira J, Hernández-Aguilera A, Luciano-Mateo F, Cabré N, Baiges-Gaya G, Nadal M, Martín-Paredero V, Camps J, Joven J, Domingo JL. Trace Elements and Paraoxonase-1 Activity in Lower Extremity Artery Disease. Biol Trace Elem Res. 2018 Mar 10. doi: 10.1007/s12011-018-1298-x.
María Ángeles Martínez, Raju Prasad, Dr. Joaquim Rovira, Dr. Vikas Kumar and Prof. Marta Schuhmacher have created a mathematical model to quantify the transferred amount of bisphenol A from pregnant women to fetus. This method has been tested with 100 pregnant women to know the fate and behavior of bisphenol A in their body and to study the impact on baby's health in the future.
You can read the full press release in the following links:
On November 21st, the EPAA partners met to build synergies on the development and acceptance of Toxicokinetics and read‐across. Held at the Renaissance Brussels Hotel, the EPAA Partners Forum brought together 33 expert participants from industry and EC, along with selected representatives from regulatory agencies and invited researchers from two large EU‐funded projects (EuroMix and EUToxRisk). Dr. Vikas Kumar from University of Rovira I Virgili (Spain) represented the EuroMix project in this meeting. Dr. Kumar presented “Toxicokinetics and read across in EuroMix” and discussed how research in EuroMix is helpful for the wider stakeholders and why collaboration is necessary for the society. The Partners Forum held on 2st of November 2017 was part of the EPAA undertakings to address one of 6 challenges as a priority: to Improve intra and inter sectorial collaboration and coordination.
EPAA is a very relevant platform to build synergies across sectors, given its multi‐sectoral structure encompassing different business sectors. Besides exchanging information between sectors about their respective research agendas and activities in the sectorial flagship initiatives, the event was meant as an opportunity for the partners to identify possibilities for synergies, table feedback and scientific input in EPAA. Discussions revolved around 4 balanced sessions aiming at covering the whole spectrum of stakeholders working on TK and read‐across: regulators, the regulated, method developers and downstream users.
At the end of the day, a scientific consensus was achieved on the following four items:
• TK data play an important role in risk assessment across all industry sectors and are subject to significant research effort by all relevant stakeholders
• TK data strengthen the read across weight of evidence; TK data should ideally be anchored towards human relevance, preferably generated using in silico and in vitro tools
• Identification and characterization of Metabolism is a key component of TK assessment in readacross
• The forum expressed confidence that significantly more progress in TK can be made if collaboration between sectors is enhanced and synergies are captured.
Specifically, the participants recommended 3 actions to tackle the use of TK and read‐across methods:
– ACTION 1: Advocate for a TK speciality section within Eurotox
– ACTION 2: Produce and manage a shopping list of open tools (open source, EPAA controlled)
– ACTION 3: Support the dissemination and training event on RVIS planned in early 2019 with TK stakeholders
The participants’ discussion was captured by a scientific writer and a scientific publication is currently under preparation.
Noelia Domínguez-Morueco, PhD student in TecnATox, is currently attending to the 8th European Meeting on Environmental Chemistry (EMEC). She will perform an oral presentation entitled: "Combining monitoring and modelling approaches for BaP characterization over a petrochemical area" on November 27, 2017.
Sakamoto M, Chan HM, Domingo JL, Koriyama C, Murata K. Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood. Environ Int. 2017 Nov 14. pii: S0160-4120(17)31561-1. doi: 10.1016/j.envint.2017.11.001.
Prof. Marta Schuhmacher and Dr. Montse Marquès will attend to the kick-off meeting of SEAFOODTOMORROW project, which will be held in Lisbon (Portugal) on November 21-23.
The main goal of SEAFOODTOMORROW is to strengthen the seafood production and processing industry in Europe by providing validated market-driven and consumer-responsive eco-innovative sustainable solutions that contribute to food security, mitigate production hazards, contribute to employment and increase consumer awareness of seafood quality and safety. The role of TecnATox will be focused on Risk Assessment (WP3), Life Cycle Assessment (WP4), and the improvement of Fishchoice: a consumer benefit-risk communication tool already developed in ECsafeSEAFOOD project (WP6).
As a part of the dissemination plan, TecnATox researchers are currently giving talks to the general population.
Francisco Sánchez-Soberón did the presentatation entitled "Has the air that we breath a good quality? How to measure and assess it" in two High Schools: IES Camí de Mar (Calafell) and IES Torredembarra (Torredembara), on November 10 and 15, respectively.
Rovira J, Domínguez-Morueco N, Nadal M, Schuhmacher M, Domingo JL. Temporal trend in the levels of polycyclic aromatic hydrocarbons emitted in a big tire landfill fire in Spain: Risc assessment for human health. J Environ Sci Health A Tox Hazard Subst Envrion Eng. 2017 Nov 7:1-8. doi: 10.1080/10934529.2017.1387023
IISPV celebrated the second edition of Scientific Retreat 2017 in Poblet Monastery on October 4-5. This is an annual scientific meeting which aims to encourage the participation and interaction between the researchers of the institute, from postdoctoral to consolidated researchers from different areas.
Francisco Sánchez and Dr. Vikas Kumar attended in representation of TecnATox. Francisco gave a talk entitled: "In-vitro metabolomics to evaluate toxicity of PM".
Laura Trabalón will defend her doctoral thesis next Monday, 6th November 2017, at 11.30h in Sala de Graus, Faculty of Chemistry, Universitat Rovira i Virgili.
Title: "Seafood as a dietary source of emerging organic contaminants. A case-study in Tarragona County, Spain".
Supervisors: Dr. Eva Pocurull Aixalà, Dr. Francesc Borrull Ballarin, Dr. Martí Nadal Lomas.
This thesis has been performed in the framework of ECsafeSEAFOOD (2013-2017).
Dr. Vikas Kumar, director of Systems Toxicology area, will participate in the panel discussion of European Partnership for Alternative Approaches to Animal Testing (EPAA) meeting on "Toxicokinetics and read across: Finding synergies for 3Rs". The overall aim is the replacement, reduction and refinement (3Rs) of animal use in regulatory testing. It will be held in Brussels on November 21, 2017.
TecnATox is managing the course Environmental epidemiology in Tarragona County, organized by Mare Terra Fundació Mediterrània. It will take place on November 16th in "sala d'actes" from "Autoritat Portuària de Tarragona".
This year is a significant milestone, since the first edition was held 25 years ago. The price of the course is 25 euros, although it is free for students and unemployed.
If you would like to attend to the XXV Scientific Workshop, please choose one of the following registration options:
1) call to the phone number 977 551 300.
2) sent an email to email@example.com.
3) go to Mediterrània offices.
Hope see you there!
Prof. Marta Schuhmacher, Dr. Vikas Kumar and Dr. Joaquim Rovira are currently participating in the HEALS annual meeting. It is taking place in the island of San Servolo, Venice, Italy, from 22th till the 25th October 2017.
There are two main goals of the meeting: 1) to follow up the research activity performed during the last year; and 2) to explain the research plan for the following year.
Last week, Prof. Marta Schuhmacher was in the POPs management International Workshop, National Implementation Plan - NIP Review and Update of the Stockholm Convention on POPs Project. It was held in Bogotá (Colombia), on 12th and 13th October 2017. As a wide recognized expert on Environmental Risk Assessment, she gave two talks:
Risks: International Experiences on risks assessment associated with unintentional POPs.
BAT and BEP Case Studies: UPOPs risk assessment recommendations.
As a part of the dissemination plan, TecnATox researchers are encouraged to communicate their last findings to both scientific and general population.
Francisco Sánchez-Soberón, PhD student in TecnATox, performed the presentatation entitled "Has the air that we breath a good quality? How to measure and assess it" in the High School "IES Narcís Oller", on last December 5.
Karri V, Kumar V, Ramos D, Oliveira E, Schuhmacher M. An in vitro cytotoxic approach to assess the toxicity of heavy metals and their binary mixtures on hippocampal HT-22 cell line. Toxicol Lett. 2017 Oct 5;282:25-36. doi: 10.1016/j.toxlet.2017.10.002. [Epub ahead of print].
Karri V, Kumar V, Ramos D, Oliveira E, Schuhmacher M. Comparative In Vitro Toxicity Evaluation of Heavy Metals (Lead, Cadmium, Arsenic, and Methylmercury) on HT-22 Hippocampal Cell Line. Biol Trace Elem Res. 2017 Oct 9. doi: 10.1007/s12011-017-1177-x. [Epub ahead of print].
Luciano-Mateo F, Cabré N, Nadal M, García-Heredia A, Baiges-Gaya G, Hernández-Aguilera A, Camps J, Joven J, Domingo JL. Serum concentrations of trace elements and their relationships with paraoxonase-1 in morbidly obese women. J Trace Elem Med Bio 48 (2018) 8-15.
Esplugas R, Llovet MI, Bellés M, Serra N, Vallvé JC, Domingo JL, Linares V. Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and 137Cs. Food Chem Toxicol. 2018 Feb 22. pii: S0278-6915(18)30120-0. doi: 10.1016/j.fct.2018.02.046
Rovira J, Nadal M, Schuhmacher M, Domingo JL. Concentrations of trace elements and PCDD/Fs around a municipal solid waste incinerator in Girona (Catalonia, Spain). Human health risks for the population living in the neighborhood. Sci Total Environ. 2018 Feb 19;630:34-45.
Francisco Sánchez Soberón, PhD candidate in TecnATox, will defend her doctoral thesis on 21st March 2018, at 11.00h in Sala de Graus, Chemical Engineering School, Universitat Rovira i Virgili.
Title: "Assessment of the human health risks and toxicity associated to particles (PM10, PM2.5 and PM1), organic pollutants and metals around cement plants".
Supervisors: Dr. Marta Schuhmacher and Dr. Joaquim Rovira.
Noelia Domínguez Morueco obtained the PhD degree with the qualitification Excellent.
The thesis entitled: "Environmental levels of PAHs and other SVOCs in a Petrochemical area. Combining monitoring and modelling tools" was supervised by Dr. Martí Nadal, Dr. Jordi Sierra and Prof. Marta Schuhmacher.
Di Paolo C, Blanco J, Cabré M, García T, Gómez M, Domingo JL. Long-term oral administration of melatonin does not improve beta-amyloid deposition, caspase, and SOD2 levels in aluminum-treated Tg2576 mice. Trace Elem. Electrolytes 2018; 35:20-31.
Our postdoctoral researcher Dr. Joaquim Rovira is the final winner of the annual Toxics Travel Award.
This year a large number of very highly meritorious applications have been presented. Nevertheless, he was identified as an outstanding candidate. You can read the full news in the following link.
Prof. Marta Schuhmacher, Dr. Joaquim Rovira and Francisco Sánchez-Soberón have been assessing the occurrence of ultrafine particles (PM1) in schools around the petrochemical complex in the framework of ULTRAPAR project. Among the huge amount of results, the high levels of PM1 in the school of Vilallonga del Camp have been highlighted. In addition, La Canonja, Sant Salvador and La Pobla de Mafumet also showed significant concentrations. The next step to be carried out is to determine the pollution source.
You can read the full press release in the following link.
Dr. Jordi Sierra and Dr. Montse Marquès have recently collaborated with the magazine "FET a TARRAGONA" (Made in Tarragona).
These researchers of TecnATox wrote a divulgation article entitled "El sòl i el sol contra la contaminació" (The soil and the Sun against the pollution). It is about the role of the soil on the photodegradation of polycyclic aromatic hydrocarbons and how the climate change will impact on the fate of these environmental pollutants. These findings are rellevant since changes on human health risks have been identified.
The presentation of the next FET a TARRAGONA (number 27) will be held next January 24 at 7.30 pm, in Cafè La Cantonada (Tarragona).
Alves RIS, Machado CS, Beda CF, Fregonesi BM, Nadal M, Sierra J, Domingo JL, Segura-Muñoz SI. Water quality assessment of the Pardo River Basin, Brazil: A multivariate approach using limnological parameters, metal concentrations and indicator bacteria. Arch Environ Contam Toxicol. 2018 Jan 5. doi: 10.1007/s00244-017-0493-7.
Dr. Joaquim Rovira was interviewed by Radioset. The last findings of TecnATox in textiles area were a topic of concern in the sports program called "Partido a partido" (Match to match).
You can follow the full interview here (34'45'').
Sharma RP, Schuhmacher M, Kumar V. The development of a pregnancy PBPK Model for Bisphenol A and its evaluation with the availbale biomonitoring data. Sci Total Environ 624, 55-68. doi: 10.1016/j.scitotenv.2017.12.023.
Dr. Joaquim Rovira, postodoctoral researcher in TecnATox, has recently appeared in several media talking about a topic of interest for the general population.
The last findings regarding to the study of "Human exposure to trace elements throigh the skin by direct contact with clothing" were the reason for these interviews. He has explained that people are exposed to a mixture of additives from textile industry through dermal contact. The harmful effects of some of them are still unknown, while others, such antimony, would be a risk for the human health in case you wear certain clothes - such as those made of polyester - uninterruptedly.
Prof. Josep Lluís Domingo has recently been interviewed by eitb (Euskal Irrati Telebista). He was invited to talk about pollutants and fish, which is a topic of concern for the general public. Prof. Domingo highlighted that fish is a save healthy food item widely present in our diet. However, we have to be aware of which species are the most polluted, according to some charactersitics, such as their level in the trofic chain or location.
You can watch the full interview in the following link.
Celeste Gisela di Paolo obtained the PhD degree with the highest qualitification Excellent Cum Laude. The thesis entitled: "Evualuación de los efectos de la exposición oral a aluminio a través de la dieta en ratones Tg 2576. Papel protector de la melatonina" was supervised by Dr. Mercedes Gómez and Prof. Josep Lluís Domingo.
Venkatanaidu Karri and Raju Prasad Sharma, PhD students in Systems Toxicology, attended to the 53rd Congress of the European Societies of Toxicology (EUROTOX), which was held in Bratislava from the 10th to the 13th of September, 2017. They presented the following posters:
Karri V, Ramos D, De Oliveira Cacheado E, Schuhmacher M, Kumar V. "Proteomics Approach for improving the Mechanisms associated with MeHg Toxicity in HT-22 Hippocampal Cell line".
Sharma RP, Kumar V, Schuhmacher M. "Development and Validation of PBPK model for DEHP and its Metabolites: Application to Cohort and Case-Control Studies".
Laia Guardia and Dr. Pia Basaure, PhD student and postdoctoral researcher, respectively, attended to the following conferences:
XVII National Congress of the Spanish Society of Neuroscience (SENC). Alicante (Spain), September 27-30, 2017.
Guardia-Escote L, Basaure P, Blanco J, Peris-Sampedro F, Cabré M, Colomina MT. "Short and long term effects of a postnatal exposure to the pesticide chlorpyrifos on learning and memory: sex and APOE genotype influences". Poster.
Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Colomina MT. "Developmental effects of postnatal exposure to the pesticide chlorpyrifos and its interaction with APOE genotype". Poster.
II International Congress of Psychobiology. Ávila (Spain), July 19-21, 2017.
Guardia-Escote L, Basaure P, Peris-Sampedro F, Cabré M, Colomina MT. "Behavioral responses to toxic and pharmacological exposures are influenced by sex and APOE genetic background". Oral presentation.
Basaure P, Guardia-Escote L, Cabré M, Peris-Sampedro F, Colomina MT. "Contribution of APOE genotype on the expression of neurobehavioral effects induced by postnatal exposure to chlorpyrifos". Poster. "Special Mention Award".
The TecnATox publication Domingo JL, Rovira J, Nadal M, Schuhmacher M. High cancer risks by exposure to PCDD/Fs in the neighborhood of an Integrated Waste Management Facility. Sci Total Environ. 2017 Jul 4;607-608:63-68. doi: 10.1016/j.scitotenv.2017.06.272. [Epub ahead of print] is in the last press release of the URV digital newspaper. This article highlights the high concentration of dioxins in air in Sant Adrià del Besós, which is up to 5 times higher than levels reported in similar industrial areas. Consequently, there is a cancer risk 2.3 times above the acceptable level, meaning one case of cancer per million.
Sharma RP, Schuhmacher M, Kumar V. Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology. Toxicol Lett. 2017 Aug 14;280:79-91. doi: 10.1016/j.toxlet.2017.08.003. [Epub ahead of print]
Heredia L, Gasol L, Ventura D, Vicens P, Torrente M. Mindfulness-based stress reduction training program increases psychological well-being, and emotional regulation, but not attentional performance. A pilot study. Mind Comp. In press. doi: 10.1016/j.mincom.2017.07.001. [Epub ahead of print]
Marquès M, Sierra J, Drotikova T, Mari M, Nadal M, Domingo JL. Concentrations of polycyclic aromatic hydrocarbons and trace elements in Arctic soils: A case-study in Svalbard. Environ Res. 2017 Aug 10;159:202-211. doi: 10.1016/j.envres.2017.08.003. [Epub ahead of print]
Dr. Marta Schumacher presented the results of the second study of human exposure to environmental pollutants after the tire landfill fire that occurred in Seseña. It was concluded that "there is no health risk for the population as a consequence of the fire". A full press release can be read in the following link.
The doctoral programme in Nanosciences, Materials and Chemical Engineering organises a day in which doctoral students have the opportunity to discuss their work and have it evaluated by a prestigious panel of experts during a poster exhibition session. The TecnATox member María Ángeles Martínez won the second award of the 1st year PhD students.
Center of Environmental Food and Toxicological Technology, Rovira i Virgili University (URV)
School of Medicine and Health Sciences (FMCS) C./ Sant Llorenç, 21 (43201) Reus, Catalonia (Spain)
Technical School of Chemical Engineering (ETSEQ) Av. Països Catalans, 26 (43007) Tarragona, Catalonia (Spain)
Faculty of Education and Psychology (FCEP) C/Carretera de Valls, s/n 26 (43007) Tarragona, Catalonia (Spain)